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  Item Reference: KCLCAL-1974-1975-450

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Annual Report of the Delegacy lxix administration on mice and rats point to link between tetrahydro- isoquinoline derivatives and ethanol dependence Κ MacLean has continued investigation into changes in brain amine metabolism in rats after administration of tetrahydrocannabinol the active principle of cannabis Current results suggest that environ- mental conditions are involved in the biochemical effects of this drug Dr Κ Morton has continued investigations on the cellular mode of action of autacoids With Miss Jozefko he has been investigating the influence of certain autacoids including histamine bradykinin and the prostaglandins on the permeability of smooth muscle to inorganic ions using tracer techniques Dr Morton presented results at the Winter Meeting of the British Pharmacological Society Dr Halliday has become involved in two of the department's long- standing interests first fluorescence microscopy of the monoamines and second the release of substances having putative transmitter or trophic functions from electrically stimulated nerve-muscle prepara- tions Dr Hoult has initiated investigations into the membrane transport of biogenic amines such as histamine and 5-hydroxytrypt- amine into blood platelets Tracer techniques are used for these experi- ments He has also collaborated with Dr Littleton's group who are investigating biochemical changes in rodents made tolerant to alcohol Dr Hoult is examining the effect of chronic alcohol administration on the functions of the liver particularly with respect to the enzyme alcohol dehydrogenase Dr Prince Mrs Elizabeth Coleshill Mr Prempeh and Mr Toates have continued their investigations into the enzymes responsible for synthesising acetylcholine in different tissues The SRC granted £11 740 over three years for an investigation of the properties of the different enzymes The MRC granted £21 478 over three years for an investi- gation of the distribution and function of the different choline acetyl- transferases in nerve tissue DEPARTMENT OF PHYSIOLOGY Number oj Students 249 60 Sc 18
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