Calendar: 1963-1964 Page 169

168 BIOPHYSICS Primary sequence determination stability of protein and nucleic acid conformations in solution Infrared and ultraviolet spectra Optical rotatory dispersion Analytical and preparative methods Relation of conformation to biological activity Principles and Methods of Autoradiography lectures Muscle Biophysics and the Molecular Basis of Contraction 10 lectures Mechanical and thermal studies on intact muscle The structure of the contractile apparatus The sliding filament mechanism The molecular structure of the filaments and the physical chemistry of the protein molecules Factors controlling contraction and relaxation Comparative studies on specialised contractile systems Energy trans- fer in living systems bioenergetics Practical Instruction 24 days Practical instruction in the techniques of light microscopy Instruc- tion in the methods of electron microscopy including preparation of supporting films shadowing fixation and embedding of biological material thin sectioning negative staining Molecular model building Elementary analysis of X-ray diffraction patterns of macromolecules Bacteriophage genetics Methods of autoradiography