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  Item Reference: KCLCAL-1957-1958-426

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xl ANNUAL REPORT First Degrees Sc Special lst Class Honours 2nd Class Honours Pass Higher Degrees Ph Hebborn The organ-specific action of drugs acting on tumour-bearing rats Sc Mrs Joyce Hurd nee Dodd study of the effects of diiFerent nitrogen mustards on amoebae During the year four post-doctoral research workers were present in the department In addition to maintenance grants etc held by research students the department continued to benefit from grants made by the Agricultural Research Council the Nuffield Foundation and the British Empire Cancer Campaign Professor Danielli was invited to give papers at the Symposium of the European Biological and Medical Research Committee on Ageing in Basle at the Ciba Symposium on Methodology of Research on Ageing at the Symposium of the Royal Society of Medicine on Antitumour Drugs at the Faraday Society Symposium on Membrane Permeability and at the Gordon Symposium on Drug Action Dr Cloudsley-Thompson gave paper at the Fifth Congress of the Society for the Study of Biological Rhythms at Stockholm During the year considerable advances have been made in the work on chemotherapy of cancer in which new approach has been developed over the past four years The primary difficulty in this field has been that drugs which will damage tumour cells will also damage normal cells It was hoped that this could be overcome by designing drugs to fit the characteristics of the tumour cells This has been attempted in the first instance by making drugs which are inert in themselves but which are turned into active compounds by the enzymes present in the tumour cells This work has developed well and of the compounds which have been made for us about one in five has been promising enough to warrant development for clinical trial The compounds were made by members of the Chemistry Department of the Chester Beatty Research Institute and more recently also by members of the Chemistry Department of Imperial College It is expected that considerable changes in clinical practice will develop as result of this work Mr Green Chief Technician was awarded the Fellowship of the Institute of Science Technology Departmental Notes
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